Why the study?
Does nitric oxide synthase inhibition with L-NAME alter blood pressure and survival in rats with desipramine-induced hypotension?
Population
Anesthetized and awake rats subjected to desipramine (DMI) toxicity or nitroprusside
Comparison
NG-nitro-L-arginine methyl ester, dexamethasone… vs Control treatment
Design
Preclinical
Follow-up
Until death (for survival experiment)
Authors
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Reverses DMI hypotension but shortens survival in rats; hypothesis-generating for NOS modulation in TCA toxicity.
Does nitric oxide synthase inhibition with L-NAME alter blood pressure and survival in rats with desipramine-induced hypotension?
Constitutive nitric oxide synthase activity contributes to desipramine-induced hypotension but appears adaptive, as inhibiting it worsens survival and ECG parameters.
Pentel et al. (1996) studied this question.
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