Key result
Inhibition of nitric oxide synthesis with L-NAME reduced the heart rate response to isoproterenol by 50% and inhibited the renin response in conscious rabbits.
Why the study?
Does inhibition of nitric oxide synthesis alter the renin and heart rate responses to beta-adrenergic stimulation in conscious rabbits?
Population
Conscious, chronically prepared rabbits
Comparison
Inhibition of nitric oxide synthesis with… vs Beta-adrenergic stimulation with isoproterenol…
Design
Preclinical
Authors
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Suggests nitric oxide modulates beta-adrenergic responses in rabbits; leaves open translation to human cardiovascular disease.
Does inhibition of nitric oxide synthesis alter the renin and heart rate responses to beta-adrenergic stimulation in conscious rabbits?
Nitric oxide is required for the full expression of renin and heart rate responses to beta-adrenergic stimulation in vivo.
Reid et al. (1994) studied this question. L-NAME vs. Isoproterenol alone was evaluated on Renin secretory response and heart rate response to beta-adrenergic stimulation. Inhibition of nitric oxide synthesis with L-NAME reduced the heart rate response to isoproterenol by 50% and inhibited the renin response in conscious rabbits.
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