Key result
The combination of an angiotensin-receptor blocker and a thiazide diuretic provides complementary effects on blood pressure reduction and is well-tolerated in patients with hypertension.
Why the study?
Does the combination of an ARB and a thiazide diuretic improve blood pressure control and cardiovascular/renal outcomes in patients with hypertension compared to monotherapy?
Does the combination of an ARB and a thiazide diuretic improve blood pressure control and cardiovascular/renal outcomes in patients with hypertension compared to monotherapy?
The combination of an ARB and a thiazide diuretic is an effective and well-tolerated strategy for patients with hypertension, especially those with poor control on monotherapy or additional risk factors.
Supports ARB-thiazide use in uncontrolled hypertension; leaves open CV/renal outcome benefits versus monotherapy.
Surveys have shown that in as many as half of patients treated for hypertension, blood pressure (BP) is not controlled to target levels; many more persons have undertreated hypertension. Uncontrolled hypertension is a serious risk factor for cardiovascular events such as stroke, heart failure, myocardial infarction and target-organ diseases. Studies have shown that strict BP control significantly reduces the occurrence of these cardiovascular outcomes, in the majority of patients, effective BP control requires two or more antihypertensive agents. The combination of an angiotensin-receptor blocker (ARB) and a thiazide diuretic is appealing, since these agents have complimentary effects on BP reduction, left ventricular hypertrophy and progression of renal diseases. In addition, this combination provide excellent tolerability. The combination of an ARB and a thiazide diuretic may be of particular value in patient populations who tend to have poor BP control on monotherapy, or have additional cardiovascular or renal risk factors.
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A Mimran (2005) conducted a review in Hypertension. Combination of an angiotensin-receptor blocker (ARB) and a thiazide diuretic vs. Monotherapy was evaluated. The combination of an angiotensin-receptor blocker and a thiazide diuretic provides complementary effects on blood pressure reduction and is well-tolerated in patients with hypertension.
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