Key result
Prolonged chlorpromazine therapy for two or more years was associated with a rare incidence of thrombocytopenia, occurring in only 1 of 245 evaluated patients (0.41%).
Why the study?
Does prolonged chlorpromazine therapy cause thrombocytopenia?
Observational (n=245)
Does prolonged chlorpromazine therapy cause thrombocytopenia?
Prolonged chlorpromazine therapy is rarely associated with the development of thrombocytopenia.
Supports low thrombocytopenia risk with prolonged chlorpromazine; leaves open causality and generalizability in larger cohorts.
Two hundred and forty-five patients who had been on chlorpromazine medication for two or more years were evaluated hematologically, including platelet estimations. Only one case was found with a relatively low platelet count coincidental with leukopenia in which no interference in bleeding or clotting mechanism could be demonstrated. From our study we conclude that the development of thrombocytopenia in patients who are on prolonged therapy with chlorpromazine is rare. We plan to evaluate the 245 patients in this study at yearly intervals.
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Shawver et al. (1960) conducted an observational in Patients on prolonged chlorpromazine therapy (n=245). Prolonged chlorpromazine therapy was evaluated on Thrombocytopenia (low platelet count). Prolonged chlorpromazine therapy for two or more years was associated with a rare incidence of thrombocytopenia, occurring in only 1 of 245 evaluated patients (0.41%).
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