Association of cord blood total creatine kinase activity with mode of delivery and APGAR score

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Background: Creatine kinase (CK), an enzyme with an important role in consumption and saving energy, especially in muscle tissue.Increased CK is predominantly used to diagnose acute myocardial infarction, Neuromuscular disorders including myopathies, muscular dystrophy, rhabdomyolysis, drug-induced myopathies etc.During child birth, several fold changes in maternal total serum CK activity is observed.Objective: Our study aimed to correlate total CK activity with mode of delivery and APGAR score in newborns.Methods: This was an eighteen months hospital based descriptive study conducted by using a structured data collecting tool.The data were analyzed using SPSS software.Results: Out of 100 newborns, 51 were delivered by full term normal vaginal delivery (FTND) and 49 by lower segment cesarean section (LSCS).Maximum mothers were in the age group of 21 to 30 years.Birth weight of most of the newborns ranged between 2.5-3.0 kgs.We observed elevated total CK activity in both the modes of delivery.Significantly higher total CK activity (p<0.001) was observed in LSCS cases as compared to FTND cases.With decreasing APGAR score, a significant increase (p<0.001) in total CK activity was observed at both 1min and 5 min.Conclusion: Our study revealed that LSCS mode of delivery and lower APGAR scores are associated with increased CK activity..