Key result
Cutting the second-order chordae during mitral valve repair increases tension on first-order chordae to a maximum of 0.4 N, which is well below their experimental breaking point of 6.8 N.
Why the study?
The importance of cutting the second-order chordae during mitral valve repair to recover anterior leaflet curvature and increase coaptation length has been slowly absorbed by the surgical world despite favorable clinical reports.
Cutting second-order chordae during mitral valve repair is biomechanically safe and helps recover anterior leaflet curvature and coaptation length, addressing chordal tethering in both primary and secondary mitral regurgitation.
The chordae tendinae connect the papillary muscles to the mitral valve. While the first-order chordae serve to secure the leaflets to maintain valve closure and prevent mitral valve prolapse, the second-order chordae are believed that they play a role in maintaining normal LV size and geometry. The papillary muscles, from where the chordae tendinae originate, function as shock absorbers that compensate for the geometric changes of the left ventricular wall. The second-order chordae connect the PMs to both trigons under tension. The tension distributed towards the second-order chordae has been demonstrate to be more than three-fold that in the first-order counterpart. Cutting the second-order chordae puts all the tension on the first-order chordae, that can go closer to their rupture point. However, it has been experimentally demonstrated that the tension where the first-order chordae break is 6.8 N, by far higher than the maximal tension reached, that is 0.4 N. Even if the clinical reports have been favorable, the importance of cutting the second-order chordae to recover curvature of the anterior leaflet and increasing the coaptation length between the mitral leaflet has been slowly absorbed by the surgical world. Nevertheless, there are progressive demonstrations that chordal tethering affects the anterior leaflet not only in secondary, but also in primary mitral regurgitation, having a not negligeable role in the long-term outcome of mitral repair.
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Calafiore et al. (2022) conducted a review in Mitral regurgitation. Cutting the second-order chordae was evaluated. Cutting the second-order chordae during mitral valve repair increases tension on first-order chordae to a maximum of 0.4 N, which is well below their experimental breaking point of 6.8 N.
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