Why the study?
Does cutting second-order chordae prevent acute ischemic mitral regurgitation in a sheep model of acute ischemia?
Population
6 sheep undergoing radiopaque marker placement and acute ischemia induced by 80 seconds of mid-circumflex…
Comparison
Cutting the largest second-order chord from each… vs Before chordal cutting
Design
Preclinical
Follow-up
Acute (80 seconds of ischemia)
Authors
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Chordal cutting fails to prevent acute ischemic MR in sheep; challenges the rationale and leaves open any role in chronic human disease.
Does cutting second-order chordae prevent acute ischemic mitral regurgitation in a sheep model of acute ischemia?
In a sheep model, cutting second-order chordae caused LV systolic dysfunction and failed to prevent acute ischemic mitral regurgitation.
Rodriguez et al. (2004) studied this question.
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