Key result
Second-order chordal cutting in sheep with chronic post-MI mitral regurgitation limited progressive left ventricular remodeling, with LVESV increasing by 30.5% vs 109% in controls (P<0.01).
Why the study?
Does second-order chordal cutting reduce left ventricular remodeling and mitral regurgitation in a sheep model of chronic ischemic mitral regurgitation?
Population
18 sheep with posterolateral myocardial infarction created by obtuse marginal branch ligation, with chronic…
Comparison
Second-order chordal cutting vs Sham surgery (n=6)
Design
Preclinical, randomized
Follow-up
mean 6.6 months post-MI
Authors
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May support chordal strategies to limit ischemic MR remodeling; hypothesis-generating in animals and requires clinical validation.
RCT (n=18)
randomized
Does second-order chordal cutting reduce left ventricular remodeling and mitral regurgitation in a sheep model of chronic ischemic mitral regurgitation?
Absolute Event Rate: 30.5% vs 109%
p-value: p=<0.01
In a sheep model of chronic ischemic mitral regurgitation, second-order chordal cutting significantly reduced the progression of left ventricular remodeling and sustained the reduction of mitral regurgitation.
Messas et al. (2010) conducted an RCT in chronic ischemic mitral regurgitation (n=18). Second-order chordal cutting vs. Sham surgery was evaluated on Increase in left ventricular end-systolic volume (LVESV) relative to chronic MI (p=<0.01). Second-order chordal cutting in sheep with chronic post-MI mitral regurgitation limited progressive left ventricular remodeling, with LVESV increasing by 30.5% vs 109% in controls (P<0.01).
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