Key result
Chordal cutting in normal sheep did not acutely decrease global or segmental left ventricular contractility, with ejection fraction remaining unchanged (54.2% vs 54.2%, P=0.96).
Why the study?
Does cutting of the central basal chordae to the anterior leaflet reduce left ventricle contractile function in normal sheep?
Population
5 normal sheep
Comparison
Cutting of the 2 central basal chordae to the… vs Before chordal cutting (baseline)
Design
Preclinical
Follow-up
Acute (immediately before and after cutting)
Authors
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Supports preclinical safety of chordal cutting; leaves open translation to human mitral repair.
Does cutting of the central basal chordae to the anterior leaflet reduce left ventricle contractile function in normal sheep?
Absolute Event Rate: 54.2% vs 54.2%
p-value: p=0.96
Severing the central basal chordae to the anterior leaflet does not acutely impair global or segmental left ventricular contractility in a normal sheep model, supporting its safety in mitral valve repair.
Messas et al. (2006) studied Normal sheep (n=5). Chordal cutting vs. Before cutting (baseline) was evaluated on Left ventricular ejection fraction (p=0.96). Chordal cutting in normal sheep did not acutely decrease global or segmental left ventricular contractility, with ejection fraction remaining unchanged (54.2% vs 54.2%, P=0.96).
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