Preclinical study demonstrates reduced toxicity and maintained antitumor activity of a water-soluble taxol derivative in tumor models, indicating safer chemotherapy delivery.
Just as effective and not as toxic, taxol derivative 1 displays antitumor activity comparable to that of the parent compound. Since 1 is water soluble, complications that arise in clinical applications of taxol may be avoided.
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Nicolaou et al. (1994) studied this question.
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