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The mechanism of the conversion of pyrimidine into 5‐ethyl‐2‐methylpyridine has been investigated. It has been proved, using the labelled compounds [1,3‐15N]pyrimidine, [4,6‐14C]pyrimidine and [5‐14C]pyrimidine, that this reaction proceeds via a mechanism, in which the pyrimidine ring is fragmentated into two molecules of HCN and one molecule of N‐methylacetaldimine. Four molecules of this imine undergo an aldol type condensation leading to 5‐ethyl‐2‐methylpyridine.
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OOSTVEEN et al. (1976) studied this question.
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