5′-Deoxy-5′-methylthioguanosine (MTG) has been identified in human urine by combined gas chromatography/mass spectrometry. Preliminary identification of MTG in the urine of a lung cancer patient was based upon mass spectral comparisons of the trimethylsilylated (TMS) urinary component to both MTA-(TMS)3 and guanosine-(TMS)5. Structural confirmation was obtained by comparing the mass spectral and chromatographic characteristics of authentic MTG to those of the urinary component.
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Hammargren et al. (1992) studied this question.
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