Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide and Glomerular Filtration Rate in Patients With Acute Heart Failure

Figure 1. ROC curve (Receiver operator characteristic curves) showed, NT-proBNP and GFR had certain prognosis value of acute heart failure in the 18-month. NT-proBNP combined with GFR had a higher prognostic value. AUCGFR = 0.677, 95%CI: 0.627–0.723, P < 0.001; Sensitivity = 49.5%, Specificity = 81.0%, Cut off point: 61.7; AUCNT−proBNP = 0.648, 95%CI: 0.598–0.695, P < 0.001; Sensitivity = 68.6%, Specificity = 53.2%, Cut off point: 2,137; AUCNT−proBNP+GFR = 0.711, 95%CI: 0.663–0.756, P < 0.001, Sensitivity = 53.5%, Specificity = 85.3%; AUCGFR~AUCNT−proBNP+GFR, P = 0.0117; AUCNT−proBNP~AUCNT−proBNP+GFR, P = 0.0384; AUCNT−proBNP~AUCGFR, P = 0.471.

Figure 2. Kaplan-meier curve analysis of NT-proBNP and GFR. (A) Kaplan-meier curve analysis showed that mortality significantly increased when NT-proBNP > 2,137 pg/ml. There were 32 missing data for NT-proBNP, 27 in the survival group, and 5 in the death group. (B) Kaplan-meier curve analysis showed that mortality significantly increased when GFR <61.7 ml/(min•1.73 m2). There were 2 missing data for GFR in the survival group.

Figure 3. Chi-square test was performed on the four groups of variables and pairwise comparisons were calculated. We used the optimal prediction points of NT-proBNP and GFR obtained by ROC curve as the criteria to divide groups in the figure. A: NT-proBNP ≤ 2,137 pg/ml, GFR ≥ 61.7 ml/(min•1.73 m2); B: NT-proBNP ≤ 2,137 pg/ml, GFR <61.7 ml/(min•1.73 m2); C: NT-proBNP > 2,137 pg/ml, GFR ≥ 61.7 ml/(min•1.73 m2); D: NT-proBNP > 2,137pg/ml, GFR <61.7 ml/(min•1.73 m2).

Figure 4. Kaplan-meier curve analysis for predicting survival status of AHF patients between the four groups. A: NT-proBNP ≤ 2,137 pg/ml, GFR ≥ 61.7 ml/(min•1.73 m2); B: NT-proBNP ≤ 2,137 pg/ml, GFR <61.7 ml/(min•1.73 m2); C: NT-proBNP > 2,137 pg/ml, GFR ≥ 61.7 ml/(min•1.73 m2); D: NT-proBNP > 2,137 pg/ml, GFR <61.7 ml/(min•1.73 m2).