Key result
Obestatin treatment ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by a high-fat diet and potentiated the beneficial effects of exercise.
Why the study?
Dietary fat intake increases cardiovascular disease risk, prompting investigation into the effects of exercise and obestatin on high-fat diet-induced cardiac hemodynamic changes.
Does exercise and obestatin improve cardiac hemodynamics and biochemical markers in a high-fat diet rat model?
Does exercise and obestatin improve cardiac hemodynamics and biochemical markers in a high-fat diet rat model?
Obestatin, alone or combined with exercise, may help maintain cardiac function and improve lipid profiles in the setting of a high-fat diet in a rat model.
Hypothesis-generating in rats; does not support clinical use of obestatin in humans.
The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle.Large amounts of dietary fat intake increase the risk of cardiovascular disease.We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes.Seventy-nine Sprague-Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks.In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25μg/kg, i.p), exercise+obestatin (25μg/kg, i.p).After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed.Hearts were removed for hemodynamic measurements with the Langendorff apparatus.Blood samples were collected for biochemical measurements.Data were analyzed by Graphpad Prism 6.0.and p<0.05 was accepted as statistically significant.Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated.And the effects of chronic obestatin treatment and exercise were studied together.Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD.Also, obestatin prevents decreasing BNP levels with highfat consumption.Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements.We believe that obestatin has the potential for the maintenance of cardiac function in HFD.
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MEMI et al. (2023) studied High-fat diet induced cardiac hemodynamic changes (n=79). Exercise and obestatin vs. Control diet or HFD alone was evaluated on Cardiac contractility and hemodynamic parameters (LVDP, heart rate, blood lipids, BNP). Obestatin treatment ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by a high-fat diet and potentiated the beneficial effects of exercise.
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