Key result
Genomic sequencing of a foot-and-mouth disease virus serotype O vaccine strain from Pakistan revealed heterogeneity in protective VP1 epitopes compared to characterized strains.
The genomic heterogeneity identified in the vaccine strain warrants further studies to determine vaccine-induced immunity and disease protection.
May compromise cross-protection in Pakistan; leaves open need for updated epitope-matched FMD vaccines.
Sequencing and subsequent analysis of a vaccine strain of foot-and-mouth disease virus serotype O is reported here. Genomic heterogeneity in the protective epitopes (VP1 protein) of the reported strain, compared to characterized strains and available sequences from Pakistan, warrants further studies to determine vaccine-induced immunity and disease protection.
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Shabbir et al. (2015) studied this question. Genomic sequencing of a foot-and-mouth disease virus serotype O vaccine strain from Pakistan revealed heterogeneity in protective VP1 epitopes compared to characterized strains.
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