Key result
Genomic analysis of Bangladesh FMD virus reveals antigenic heterogeneity, deletions, and insertions versus the vaccine strain.
Why the study?
Foot-and-mouth disease virus serotype O circulating in Bangladesh exhibits genomic differences compared to the available vaccine strain, necessitating complete genome sequencing.
Genomic variations from vaccine strain in this FMDV O isolate may affect matching; leaves open need for updated surveillance and antigenic studies.
Foot-and-mouth disease (FMD) is a highly infectious enzootic disease caused by FMD virus. The complete genome sequence of a circulatory FMD virus (FMDV) serotype O isolated from Natore, Bangladesh, is reported here. Genomic analysis revealed antigenic heterogeneity within the VP1 region, a fragment deletion, and insertions at the 5' untranslated region (UTR) and 3A region compared to the genome of the available vaccine strain.
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Sultana et al. (2014) studied Foot-and-mouth disease. Genome sequencing of FMDV serotype O vs. Available vaccine strain was evaluated on Genomic characteristics. Genomic analysis of a circulatory FMD virus serotype O from Bangladesh revealed antigenic heterogeneity, a fragment deletion, and insertions compared to the available vaccine strain.
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