What does this research mean for the field?

The foot-and-mouth disease virus serotype A isolate BDSH_01 circulating in Bangladesh exhibits sequence divergence from current vaccine strains and clusters phylogenetically with regional strains, indicating transboundary transmission. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to sequence and analyze the genome of a circulating foot-and-mouth disease virus in Bangladesh.

March 1, 2026Open Access

Complete genome sequence of a circulating foot-and-mouth disease virus serotype A isolated from recent outbreaks in Bangladesh

Key Result

The complete genome of FMDV serotype A isolate BDSH_01 from Bangladesh shows divergence from vaccine strains, indicating transboundary spread and epidemiological significance.

Key Points

This research aims to sequence and analyze the genome of a circulating foot-and-mouth disease virus in Bangladesh.
Isolated the foot-and-mouth disease virus serotype A from recent outbreaks in Bangladesh.
Performed complete genome sequencing of the virus isolate.
Conducted phylogenetic analysis to determine genetic relationships with other strains.
The genome sequence comprises 8,140 nucleotides and encodes a 2,333-amino acid polyprotein.
Phylogenetic analysis reveals clustering with recent regional strains, indicating transboundary transmission.
Divergence from existing vaccine strains emphasizes the virus's epidemiological and immunological importance.

Structured PICO

Population

Foot-and-mouth disease virus serotype A isolate BDSH_01 from Bangladesh

Outcome

Complete genome sequence

The complete genome sequence of FMDV serotype A isolate BDSH_01 from Bangladesh reveals sequence divergence from vaccine strains, highlighting its epidemiological and immunological significance.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

We present the complete genome sequence of foot-and-mouth disease virus serotype A isolate BDSH₀1 from Bangladesh. The 8, 140-nucleotide genome encodes a 2, 333-aa polyprotein with conserved motifs. Phylogenetically, within lineage A/ASIA/G-VII, clustering with recent regional strains indicates transboundary transmission. Sequence divergence from vaccine strains highlights its epidemiological and immunological significance.