Key result
A Bangladeshi foot-and-mouth disease virus type A strain exhibited an 84-nucleotide 5'-UTR insertion, a lengthened poly(C) tract, and VP1 amino acid substitutions compared to the vaccine strain.
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Warrants vigilance for potential FMDV vaccine mismatch; leaves open needs for regional strain surveillance and updates.
The complete genome sequence of a foot-and-and mouth disease virus (FMDV) type A strain (BAN/GA/Sa-197/2013), isolated from Gazipur in Bangladesh, revealed an 84-nucleotide insertion within the 5'-untranslated region (UTR), a lengthened poly(C) tract, and amino acid substitutions at the VP1 region compared to the available genome sequence of the vaccine strain (GenBank accession no. HM854025).
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Ullah et al. (2014) studied this question. A Bangladeshi foot-and-mouth disease virus type A strain exhibited an 84-nucleotide 5'-UTR insertion, a lengthened poly(C) tract, and VP1 amino acid substitutions compared to the vaccine strain.
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