Key result
Rare foot-and-mouth virus strain O/ME-SA/Ind2001BD2 exhibits critical antigenic capsid substitutions versus the existing vaccine strain.
Why the study?
A representative genome sequence of the rare FMDV O/ME-SA/Ind2001BD2 sublineage from Bangladesh was not previously reported, limiting understanding of its antigenic differences from vaccine strains.
Key points are not available for this paper at this time.
Population
FMDV strain O/ME-SA/Ind2001BD2 isolated exclusively from Bangladesh
Comparison
Amino acid substitutions compared to vaccine strain O/India/R2/75 and contemporary FMDV serotype O isolates
Design
Genome sequencing and comparative analysis
No takes yet. Share an insight, caveat, or question.
May signal need for updated FMDV vaccine matching in Bangladesh; leaves open cross-protection efficacy pending antigenic studies.
Alam et al. (2019) studied this question. The rare foot-and-mouth disease virus strain O/ME-SA/Ind2001BD2 exhibits amino acid substitutions at critical antigenic capsid sites compared to the existing O/India/R2/75 vaccine strain.
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