August 1, 2008EuroIntervention
Safety in simple versus complex stenting of coronary artery bifurcation lesions. The Nordic Bifurcation Study 14-month follow-up results
Key result
Complex stenting of coronary bifurcation lesions yielded similar rates of MACE (8.2% vs 9.5%, ns) and definite stent thrombosis (0.5% vs 1.0%, ns) compared to simple stenting at 14 months.
Why the study?
Does a complex stenting strategy reduce stent thrombosis and major adverse cardiac events compared to a simple stenting strategy in patients with coronary bifurcation lesions?
Population
413 patients with a coronary bifurcation lesion
Comparison
Complex stenting strategy using sirolimus… vs Simple treatment strategy using sirolimus…
Design
RCT, randomised
Follow-up
14 months
Authors
Discussion
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Implication
Simple stenting suffices for bifurcation lesions; confirms no MACE or thrombosis benefit from complex techniques in this RCT.
Study Design
Type
RCT (n=413)
Multicenter
Yes
Structured PICO
Does a complex stenting strategy reduce stent thrombosis and major adverse cardiac events compared to a simple stenting strategy in patients with coronary bifurcation lesions?
P
Population
413 patients with a coronary bifurcation lesion randomized to simple or complex stenting strategies and followed for 14 months.
I
Intervention
Complex stenting strategy (stenting of both main vessel and side branch) using sirolimus eluting stents (SES)
C
Comparator
Simple treatment strategy (stenting of main vessel and optional stenting of side branch) using sirolimus eluting stents (SES)
O
Outcome
Stent thrombosis and major adverse cardiac events (MACE) at 14 monthscomposite
Main Result
Absolute Event Rate: 8.2% vs 9.5%
p-value: p=ns
At 14 months, simple and complex stenting strategies for coronary bifurcation lesions using sirolimus-eluting stents showed similarly low rates of stent thrombosis and MACE.
Cite This Study
Galløe et al. (2008) conducted an RCT in Coronary artery bifurcation lesions (n=413). Complex stenting strategy (main vessel and side branch) vs. Simple stenting strategy (main vessel and optional side branch) was evaluated on Major adverse cardiac events (MACE) (p=ns). Complex stenting of coronary bifurcation lesions yielded similar rates of MACE (8.2% vs 9.5%, ns) and definite stent thrombosis (0.5% vs 1.0%, ns) compared to simple stenting at 14 months.