Key result
Subclinical autonomic dysfunction was present in 80% of patients with advanced lymphoma at presentation, with significant improvement in autonomic scores following chemotherapy.
Why the study?
Does combination chemotherapy improve cardiovascular autonomic function in patients with advanced lymphoma?
Population
20 consecutive patients with advanced Hodgkin's disease, high-grade non-Hodgkin's lymphoma, or low-grade…
Comparison
Combination chemotherapy including vinca alkaloids vs Baseline (prior to chemotherapy)
Design
Cohort
Follow-up
Following completion of chemotherapy
Authors
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Supports autonomic screening in advanced lymphoma; leaves open chemotherapy's causal role versus paraneoplastic resolution.
Cohort (n=20)
Does combination chemotherapy improve cardiovascular autonomic function in patients with advanced lymphoma?
Subclinical autonomic dysfunction is highly prevalent in patients with advanced lymphoma and improves with chemotherapy, suggesting a paraneoplastic etiology.
Turner et al. (1993) conducted a cohort in Hodgkin's disease and non-Hodgkin's lymphoma (n=20). Combination chemotherapy including vinca alkaloids vs. Pre-chemotherapy baseline was evaluated on Abnormal cardiovascular autonomic function tests at presentation. Subclinical autonomic dysfunction was present in 80% of patients with advanced lymphoma at presentation, with significant improvement in autonomic scores following chemotherapy.
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