Key result
Current lymphoma patients exhibited autonomic changes compared to cured patients or healthy controls, suggesting autonomic dysfunction in lymphoma is a transient paraneoplastic syndrome.
Why the study?
Is autonomic dysfunction in patients with lymphoma related to chemotherapy or a paraneoplastic syndrome?
Population
40 patients with current or cured Hodgkin or non-Hodgkin lymphoma and 40 healthy controls, matched for age…
Design
Case-control
Authors
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Autonomic dysfunction may be transient in active lymphoma; supports paraneoplastic hypothesis but leaves open chemotherapy role pending prospective studies.
Case-Control (n=80)
Is autonomic dysfunction in patients with lymphoma related to chemotherapy or a paraneoplastic syndrome?
Autonomic dysfunction in lymphoma appears to be a transient manifestation of a paraneoplastic syndrome.
Bilora et al. (2010) conducted a case-control in Hodgkin and non-Hodgkin lymphoma (n=80). Current or cured Hodgkin or non-Hodgkin lymphoma vs. Healthy controls was evaluated on Autonomic dysfunction (evaluated via Deep Breath, Valsalva Maneuver, Hand Grip, Lying to Standing, Tilt Test). Current lymphoma patients exhibited autonomic changes compared to cured patients or healthy controls, suggesting autonomic dysfunction in lymphoma is a transient paraneoplastic syndrome.
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