Key result
PST 2238 reduced blood pressure and normalized renal Na-K pump activity in Milan hypertensive rats without inducing diuretic activity or associated metabolic alterations.
Why the study?
Does PST 2238 reduce blood pressure without diuretic activity in Milan hypertensive rats compared to HCTZ?
Population
Milan hypertensive rats
Comparison
PST 2238 (oral doses of micro g/kg) vs Hydrochlorothiazide (HCTZ) 40 mg/kg orally
Design
Preclinical
Authors
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May represent a novel non-diuretic antihypertensive mechanism in rats; leaves open translation to human hypertension.
Does PST 2238 reduce blood pressure without diuretic activity in Milan hypertensive rats compared to HCTZ?
PST 2238 is a novel antihypertensive agent that lowers blood pressure by normalizing renal Na-K pump function without the diuretic or metabolic side effects seen with thiazides in a rat model.
Ferrandi et al. (2002) studied Hypertension. PST 2238 vs. HCTZ (40 mg/kg orally) was evaluated on Blood pressure, renal Na-K pump activity, and diuretic activity. PST 2238 reduced blood pressure and normalized renal Na-K pump activity in Milan hypertensive rats without inducing diuretic activity or associated metabolic alterations.
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