Key result
The ACE-DD genotype was associated with a significantly shorter time from nephropathy diagnosis to end-stage renal disease compared to other genotypes (10.45 vs 19.5 years; P<0.034).
Why the study?
Does the ACE-DD genotype increase the risk of progression to end-stage renal disease in patients with nephropathy?
Population
290 subjects, comprising 161 patients from a Nephrology Department and 129 control subjects.
Comparison
ACE-DD genotype vs Other ACE genotypes (including II and ID)
Design
Cohort
Follow-up
44 months
Authors
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ACE-DD may support risk stratification in nephropathy; hypothesis-generating and should not yet change practice.
Observational (n=290)
No
Does the ACE-DD genotype increase the risk of progression to end-stage renal disease in patients with nephropathy?
Absolute Event Rate: 10.45% vs 19.5%
p-value: p=<0.034
The ACE-DD genotype is associated with a higher risk and faster progression of nephropathy to end-stage renal disease.
Ortiz et al. (2003) conducted an observational in Nephropathy and end-stage renal disease (n=290). ACE-DD genotype vs. Other ACE genotypes (II, ID) was evaluated on Time between diagnosis of nephropathy and end-stage renal disease (years) (p=<0.034). The ACE-DD genotype was associated with a significantly shorter time from nephropathy diagnosis to end-stage renal disease compared to other genotypes (10.45 vs 19.5 years; P<0.034).
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