Key result
Atorvastatin reduces muscle sympathetic nerve activity in patients with mild to moderate hypertension, likely via antioxidant effects in the rostral ventrolateral medulla.
Atorvastatin may exert blood pressure-lowering effects through sympathoinhibition mediated by antioxidant mechanisms in the rostral ventrolateral medulla.
he 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are potent inhibitors of cholesterol biosynthesis.Statins slow the progression, and foster the regression, of atherosclerosis, resulting in an improvement of cardiovascular outcomes in humans with elevated serum cholesterol levels. 1 In addition, statins improve endothelial function as a pleiotropic effect.2 Interestingly, a recent study suggests that statins reduce blood pressure in patients with hypertension.3 However, the mechanisms involved in the depressor response to statins may not be because of improved endothelial dysfunction alone, because other mechanisms, such as effects on the sympathetic nervous system (SNS), have not been fully evaluated in humans.
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Kishi et al. (2010) conducted an editorial in Hypertension. Atorvastatin vs. Placebo was evaluated on Muscle sympathetic nerve activity (MSNA). Atorvastatin reduces muscle sympathetic nerve activity in patients with mild to moderate hypertension, likely via antioxidant effects in the rostral ventrolateral medulla.
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