Key result
The relative apical sparing sign on two-dimensional speckle-tracking echocardiography was related to a lack of hyperenhancement at late gadolinium enhancement imaging in cardiac MRI in a patient with cardiac amyloidosis.
Case Report (n=1)
No
This is the first report demonstrating that the echocardiographic sign of relative apical sparing correlates with a lack of hyperenhancement on cardiac MRI in cardiac amyloidosis.
May link speckle-tracking echo to MRI in amyloidosis; hypothesis-generating and requires prospective validation before clinical use.
Amyloidosis is a disease characterized by the extracellular deposition of the protein amyloid. It is a multiorgan disease, and cardiac involvement is not uncommon, generally in the form of a restrictive cardiomyopathy. Typical aspects of cardiac amyloidosis have been described at echocardiography and magnetic resonance imaging (MRI). In particular, the relative apical sparing at two-dimensional speckle-tracking echocardiography has been reported to be specific for cardiac amyloidosis. In our case, we report for the first time that this echocardiographic sign is related to lack of hyperenhancement at late gadolinium enhancement imaging in cardiac MRI.
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Mele et al. (2017) conducted a case report in Cardiac amyloidosis (n=1). Two-dimensional speckle-tracking echocardiography and cardiac MRI was evaluated on Correlation between 2D-STE relative apical sparing and late gadolinium enhancement on cardiac MRI. The relative apical sparing sign on two-dimensional speckle-tracking echocardiography was related to a lack of hyperenhancement at late gadolinium enhancement imaging in cardiac MRI in a patient with cardiac amyloidosis.
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