Key result
A generalised tonic clonic seizure in a young woman was associated with the development of reverse Takotsubo cardiomyopathy, characterized by basal akinesia with preserved apical contractility.
Case Report (n=1)
Reverse Takotsubo cardiomyopathy is a rare variant that can be triggered by a tonic clonic seizure, highlighting the need for cardiac evaluation in such neurological presentations.
Post-seizure troponin rise with echo changes may indicate injury; hypothesis-generating for cardiac evaluation in brain tumor patients.
A woman in her 30s presented with generalised tonic clonic seizure secondary to known pilocytic astrocytoma. This seizure activity resolved spontaneously after 5 min. On clinical assessment, she was neurologically stable and further neurological investigations did not reveal progression of previously recognised pilocytic astrocytoma. Incidentally, she was found to have an elevated troponin, which significantly increased on serial assessment. ECG was unremarkable and echocardiography revealed regional wall motion abnormalities involving basal segments of the left ventricle with apical sparing. She underwent cardiac MRI, which confirmed the presence of regional wall motion abnormalities seen on echocardiography; however, there was no evidence of myocardial oedema or late gadolinium enhancement. Subsequently, she had an invasive coronary angiogram with intravascular ultrasound which ruled out acute coronary plaque event and coronary dissection. In view of the above, a diagnosis of reverse Takotsubo cardiomyopathy was made. This is a relatively rare entity characterised by the presence of akinesia/hypokinesia in the basal segments with preserved apical contractility; often seen in younger patients.
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Ali et al. (2022) conducted a case report in Reverse Takotsubo cardiomyopathy (n=1). Tonic clonic seizure was evaluated on Diagnosis of reverse Takotsubo cardiomyopathy. A generalised tonic clonic seizure in a young woman was associated with the development of reverse Takotsubo cardiomyopathy, characterized by basal akinesia with preserved apical contractility.
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