Quantitative pharmacodynamic (PD) methods are used to assess the effect of a drug on its target. The use of these methods in clinical cancer studies has increased enormously with the advent of targeted therapies in the past years. To ensure that quantitative PD methods meet their expectations, methods need to be validated according to internationally recognized standards for amongst others specificity, accuracy, sensitivity, precision and stability.
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Pluim et al. (2021) studied this question.
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