Key result
Higher habitual dietary intake of total flavonoids was associated with significantly lower odds of extensive abdominal aortic calcification in older women (OR 0.64; 95% CI 0.43-0.95).
Why the study?
Abdominal aortic calcification predicts vascular disease events, and prior findings linked apple intake to lower calcification, but whether total dietary flavonoid intake impacts abdominal aortic calcification remained unknown.
Does higher habitual dietary flavonoid intake reduce extensive abdominal aortic calcification in older women?
Cohort
Does higher habitual dietary flavonoid intake reduce extensive abdominal aortic calcification in older women?
Odds Ratio: 0.64 (95% CI 0.43–0.95)
Higher habitual dietary flavonoid intake, particularly from black tea, is associated with lower odds of extensive abdominal aortic calcification in older women.
Higher flavonoid intake may inform AAC risk stratification; extends prior apple observations but leaves open causal effects in prospective data.
BACKGROUND: The extent of abdominal aortic calcification (AAC) is a major predictor of vascular disease events. We have previously found regular apple intake, a major source of dietary flavonoids, associates with lower AAC. Whether total dietary flavonoid intake impacts AAC remains unknown. Here, we extend our observations to habitual intakes of total flavonoids, flavonoid subclasses, and specific flavonoid-containing foods, with the odds of extensive AAC. METHODS: ) from the PLSAW (Perth Longitudinal Study of Ageing Women). Flavonoid intake was calculated from food-frequency questionnaires. Calcifications of the abdominal aorta were assessed on lateral lumbar spine images and categorized as less extensive or extensive. Logistic regression was used to investigate associations. RESULTS: After adjusting for demographic, lifestyle and dietary confounders, participants with higher (Q4), compared with lower (Q1) intakes, of total flavonoids, flavan-3-ols, and flavonols had 36% (odds ratio [95% CI], 0.64 [0.43-0.95]), 39% (0.61 [0.40-0.93]) and 38% (0.62 [0.42-0.92]) lower odds of extensive AAC, respectively. In food-based analyses, higher black tea intake, the main source of total flavonoids (75.9%), associated with significantly lower odds of extensive AAC (2-6 cups/d had 16%-42% lower odds compared with 0 daily intake). In a subset of nonconsumers of black tea, the association of total flavonoid intake with AAC remained (Q4 versus Q1 odds ratio [95% CI], 0.11 [0.02-0.54]). CONCLUSIONS: In older women, greater habitual dietary flavonoid intake associates with less extensive AAC.
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Parmenter et al. (2022) conducted a cohort in Abdominal aortic calcification. Higher habitual dietary flavonoid intake (Q4) vs. Lower habitual dietary flavonoid intake (Q1) was evaluated on Extensive abdominal aortic calcification (OR 0.64, 95% CI 0.43-0.95). Higher habitual dietary intake of total flavonoids was associated with significantly lower odds of extensive abdominal aortic calcification in older women (OR 0.64; 95% CI 0.43-0.95).
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