Key result
RAS gene polymorphisms (ACE I/D and AGT M/T) showed no significant relationship with the progression of diabetic retinopathy in Chinese patients with type 1 diabetes after adjusting for confounders.
Why the study?
Do RAS gene polymorphisms and hypertension interact to affect the development of diabetic retinopathy in Chinese patients with type 1 diabetes?
Cross-Sectional (n=311)
Do RAS gene polymorphisms and hypertension interact to affect the development of diabetic retinopathy in Chinese patients with type 1 diabetes?
There is no significant independent relationship between ACE I/D and AGT M/T polymorphisms and the progression of diabetic retinopathy in Chinese patients with type 1 diabetes after adjusting for confounding factors, though an interaction with hypertension may exist.
Answers are grounded in this paper and cite their sources.
May indicate immune-metabolic link in diabetes; leaves open clinical relevance pending larger prospective validation.
// Yong-Chao Qiao 1 , Yan-Hong Pan 2 , Yan Xu 3 , Xiao-Xi Zhang 2, 4 and Hai-Lu Zhao 1, 2, 4 1 Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China 2 Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin, Guangxi, China 3 Department of Laboratory Medicine, Hunan Aerospace Hospital, Changsha, Hunan, China 4 Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin, Guangxi, China Correspondence to: Hai-Lu Zhao, email: zhaohailu9@126.com Keywords: type 1 diabetes mellitus; gene polymorphisms; genotype; diabetic retinopathy; renin-angiotensin system Received: November 19, 2017 Accepted: January 03, 2018 Published: January 09, 2018 ABSTRACT Background: The objective of this research was to investigate the interaction of RAS gene polymorphisms in Chinese patients with type 1 diabetes mellitus (T1DM) and diabetic retinopathy (DR). Methods: Genomic DNA was extracted from peripheral blood leukocytes and genotyping for the angiotensin converting enzyme (ACE) gene I/D and angiotensinogen (AGT) gene M/T polymorphisms was performed using the polymerase chain reaction method. 311 T1DM patients were recruited for the assessment of ACE and AGT polymorphisms relating to DR. Results: Compared with the diabetic non-retinopathy (DNR) patients, DR patients had lower proportion of diabetic nephropathy ( p <0.001) and M allele ( p =0.013). Intriguingly, the frequency D allele ( p =0.035) was lower in DR patients with hypertension, as well as DD ( p =0.003) and DI genotype ( p =0.012) in DR patients with normal blood pressure after multiple tests with Bonferroni correction, but D allele ( p =0.025) displayed higher in normotensive patients with T1DM. Logistic regression analyses indicated that no significant relationship existed about the genotype and allele polymorphisms with the progress of DR after adjusting for confounding factors. Conclusions: Interaction of hypertension and the RAS gene polymorphisms might have a role in the DR development in Chinese T1DM patients.
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Qiao et al. (2018) conducted a cross-sectional in Type 1 diabetes mellitus and diabetic retinopathy (n=311). RAS gene polymorphisms (ACE I/D and AGT M/T) vs. Diabetic non-retinopathy patients was evaluated on Progress of diabetic retinopathy. RAS gene polymorphisms (ACE I/D and AGT M/T) showed no significant relationship with the progression of diabetic retinopathy in Chinese patients with type 1 diabetes after adjusting for confounders.
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