Key result
Noninvasive motion ventilation with periodic acceleration significantly decreased systemic vascular resistance by approximately 30% and pulmonary vascular resistance by 100% compared to conventional mechanical ventilation.
Why the study?
Does noninvasive motion ventilation with periodic acceleration improve hemodynamics in a piglet model of meconium aspiration compared to conventional mechanical ventilation?
Does noninvasive motion ventilation with periodic acceleration improve hemodynamics in a piglet model of meconium aspiration compared to conventional mechanical ventilation?
Noninvasive motion ventilation through periodic acceleration decreases systemic and pulmonary vascular resistance in a piglet model of meconium aspiration.
Answers are grounded in this paper and cite their sources.
Does not alter neonatal ventilation practice; hypothesis-generating for periodic acceleration in pulmonary hypertension models.
The hemodynamic effects of periodic acceleration (pG(z)), induced in the spinal axis with noninvasive motion ventilation (NIMV), were studied in a piglet model of pulmonary hypertension associated with meconium aspiration. Animals (n = 12) were anesthetized, paralyzed, intubated, and supported by conventional mechanical ventilation (CMV). Thirty minutes after tracheal instillation of meconium solution (6 ml/kg), either CMV (n = 6) was continued or NIMV (n = 6) was initiated. Changes in systemic and pulmonary hemodynamics and arterial blood gases were tracked for 2 h after aspiration. Thermodilution, cardiac output, and heart rate were not significantly different after meconium aspiration in the pG(z) group relative to the CMV controls. Aortic pressure and systemic vascular resistance were significantly lower (approximately 30%) after meconium aspiration in NIMV animals relative to CMV animals. Pulmonary arterial pressure and pulmonary vascular resistance were also significantly lower, by 100%, after aspiration of meconium in the NIMV animals compared with the CMV controls. Meconium aspiration significantly decreased total respiratory compliance by approximately 50% and increased total respiratory resistance by approximately 100% in both CMV and NIMV animals, but such alterations did not differ between the two groups. Both CMV and NIMV satisfactorily supported ventilation in these paralyzed animals. In conclusion, NIMV through pG(z) in the spinal axis decreased systemic and pulmonary vascular resistance in piglets after meconium aspiration.
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Adams et al. (2000) studied Pulmonary hypertension associated with meconium aspiration (n=12). Noninvasive motion ventilation (NIMV) with periodic acceleration (pGz) vs. Conventional mechanical ventilation (CMV) was evaluated on Systemic and pulmonary hemodynamics. Noninvasive motion ventilation with periodic acceleration significantly decreased systemic vascular resistance by approximately 30% and pulmonary vascular resistance by 100% compared to conventional mechanical ventilation.
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