Key result
The ACE gene II genotype was associated with a higher incidence of retinopathy of prematurity (p < 0.01), whereas the DD genotype was associated with progression to advanced stages (p < 0.04).
Why the study?
Is the ACE gene I/D polymorphism associated with the development and progression of retinopathy of prematurity in premature infants?
Case-Control (n=181)
Is the ACE gene I/D polymorphism associated with the development and progression of retinopathy of prematurity in premature infants?
p-value: p=<0.01
The ACE gene I/D polymorphism may be associated with the development and severity of retinopathy of prematurity in Kuwaiti infants.
Retinopathy of prematurity (ROP) is a disease characterized by neovascularization which occurs in infants with short gestational age and low birth weight and can lead to retinal detachment and blindness. In a proportion of ROP cases, the disease progresses to advanced stages despite rigorous intervention. The genotypes for angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism were determined in 181 premature Kuwaiti infants using a polymerase chain reaction (PCR) method. The incidence of different I/D genotypes was compared in ROP cases (n = 74) and non-ROP controls (n = 107) and within 2 subgroups of ROP patients: (1) in which ROP regressed spontaneously (stages 1-3, n = 53), and (2) in which ROP progressed to advanced stages (stages 4 and 5, n = 21). When the ROP cases were considered collectively as one group, the incidence of the DD genotype was almost identical to that of non-ROP controls. The incidence of heterozygous ID genotype was higher in non-ROP controls. The incidence of the II genotype was higher in ROP cases compared to non-ROP controls (p < 0.01). In contrast to this, when ROP cases were divided in 2 subgroups the incidence of the DD genotype was significantly higher in advanced stage ROP cases compared to spontaneously regressing ROP cases (p < 0.04). The incidences of ID and II genotypes were not significantly different amongst the 2 subgroups of ROP patients.
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Haider et al. (2002) conducted a case-control in Retinopathy of Prematurity (n=181). Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism vs. Non-ROP controls and spontaneously regressing ROP cases was evaluated on Incidence of ACE gene I/D genotypes (p=<0.01). The ACE gene II genotype was associated with a higher incidence of retinopathy of prematurity (p < 0.01), whereas the DD genotype was associated with progression to advanced stages (p < 0.04).
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