Why the study?
Is the ACE I/D polymorphism associated with an increased risk of retinal artery occlusion?
Is the ACE I/D polymorphism associated with an increased risk of retinal artery occlusion?
The ACE I/D polymorphism is not a major risk factor for retinal artery occlusion, whereas arterial hypertension and smoking are predictive.
ACE I/D polymorphism shows no link to retinal artery occlusion risk; leaves open other genetic contributions while reinforcing hypertension and smoking as key factors.
PURPOSE: An insertion/deletion (I/D) polymorphism of the gene for angiotensin-converting enzyme (ACE) is associated with higher ACE plasma levels and activity. This enzyme is known to play an important role in blood pressure regulation and the ACE I/D gene polymorphism has been suggested as a risk factor for atherosclerotic vascular diseases. The purpose of the present study was to investigate a hypothesized association between the ACE I/D polymorphism and retinal artery occlusion (RAO). METHODS: A total of 159 patients with RAO and 304 control subjects were enrolled in the present retrospective case-control study. ACE I/D genotypes were determined by polymerase chain reaction. RESULTS: Allelic frequencies and genotype distribution of the ACE I/D polymorphism did not significantly differ between patients and control subjects (ACE DD 25.8% versus 28.0%; p = 0.36). A logistic regression analysis predicted the presence of RAO by arterial hypertension and current smoking status, but not by ACE I/D genotypes. CONCLUSION: Our data suggest that the ACE I/D polymorphism is not a major risk factor for RAO.
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Schäfer et al. (2006) studied this question.
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