Key result
The heterozygous AGT 174TM genotype was associated with a higher risk of cerebral stroke (OR 1.52; 95% CI 1.08-2.15; p=0.02), an association that was observed exclusively in women.
Why the study?
Are the M235T and T174M polymorphisms of the angiotensinogen gene associated with a higher risk of cerebral stroke?
Case-Control (n=638)
Are the M235T and T174M polymorphisms of the angiotensinogen gene associated with a higher risk of cerebral stroke?
Odds Ratio: 1.52 (95% CI 1.08–2.15)
p-value: p=0.02
The AGT T174M polymorphism is associated with an increased risk of cerebral stroke, specifically in women.
May increase stroke risk in women; hypothesis-generating and requires prospective replication before clinical consideration.
AIM: To study the association of M235T (rs699) and T174M (rs4762) polymorphisms of the angiotensinogen (AGT) gene with the risk of cerebral stroke (CS) in the Russians of the Central Chernozem Region. MATERIALS AND METHODS: A total of 638 DNA samples obtained from 353 patients with CS and 285 sex- and age-matched healthy individuals were examined. The polymorphisms were genotyped by polymerase chain reaction (T174M) and TaqMan allelic discrimination (M235T) assays. RESULTS: Heterozygous AGT 174TM genotype carriers were found to be at a higher risk for CS (odd ratio (OR) = 1.52; 95% confidence interval (CI), 1.08-2.15; p = 0.02). A gender-stratified analysis showed that the mutant 174M allele (OR = 1.86; 95% CI, 1.14-3.03, p = 0.01) and variant 174TM and 174MM genotypes (OR = 1.86; 95% CI, 1.09-3.20; p = 0.02) were associated with the higher risk of cerebral stroke in women. CONCLUSION: The association of AGT T174M polymorphism with the risk of CS was first found; but the higher risk of the disease in the carriers of variant alleles and genotypes was observed in the women only.
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Стецкая et al. (2014) conducted a case-control in Cerebral stroke (n=638). AGT T174M polymorphism vs. Non-carriers was evaluated on Cerebral stroke (OR 1.52, 95% CI 1.08-2.15, p=0.02). The heterozygous AGT 174TM genotype was associated with a higher risk of cerebral stroke (OR 1.52; 95% CI 1.08-2.15; p=0.02), an association that was observed exclusively in women.
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