Formulation and Evaluation of Deflazacort Loaded Gelatin Microspheres

In the present study formulation and characteristic of microspheres of Deflazacort using gelatin in a sustained release form, to overcome drug resistance and dosing non-compliance in patients.Deflazacort is used as an antiinflammatory belonging to a systemic corticosteroid and it was successfully encapsulated into carrier polymer gelatin and cross-linked with glutaraldehyde.The effect of gelatin concentration and cross-linking agent was evaluated with respect to surface characteristic particle size, entrapment efficiency, micromeritics study and in vitro release study.Infrared spectroscopic analysis confirmed the absence of any drug polymer interaction.Drug entrapment efficiency for deflazacort F4 formulation reached to highest level of 86.5% and percentage yield to 89.0%.The formulated microspheres gave 84.94% drug release in a sustained manner for 12 h.This gave hope for the possibility of single dose treatment for patients.The kinetics analysis of the drug release from the gelatin microspheres follows first order and anomalous transport mechanism.