Key result
In patients undergoing resection for gastrointestinal malignancies, cirrhosis was associated with significantly higher in-hospital mortality (8.9% vs 2.8%; OR 3.0, 95% CI 2.5-3.7).
Why the study?
Does cirrhosis increase the risk of in-hospital mortality and worsen transitional outcomes in patients undergoing resection for gastrointestinal malignancy?
Population
106,729 patients who underwent resection for gastrointestinal malignancy identified from the National…
Comparison
Resection for GI malignancy in patients with… vs Resection for GI malignancy in patients without…
Design
Cohort
Follow-up
In-hospital
Authors
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Heightens perioperative risk awareness in cirrhotic GI cancer patients; supports prospective studies on mitigation before changing practice.
Cohort (n=106,729)
Yes
Does cirrhosis increase the risk of in-hospital mortality and worsen transitional outcomes in patients undergoing resection for gastrointestinal malignancy?
Odds Ratio: 3 (95% CI 2.5–3.7)
Absolute Event Rate: 8.9% vs 2.8%
p-value: p=<.001
Cirrhosis is an independent predictor of in-hospital mortality and nonhome discharge following resection for GI malignancy, with mortality risk driven primarily by moderate to severe liver dysfunction.
Artinyan et al. (2011) conducted a cohort in Gastrointestinal malignancy (n=106,729). Cirrhosis vs. No cirrhosis was evaluated on In-hospital mortality (OR 3.0, 95% CI 2.5-3.7, p=<.001). In patients undergoing resection for gastrointestinal malignancies, cirrhosis was associated with significantly higher in-hospital mortality (8.9% vs 2.8%; OR 3.0, 95% CI 2.5-3.7).
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