Key result
Serotonergic drugs and their interactions can cause serotonin syndrome, a potentially fatal condition with an unknown but probably rising frequency.
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Design
Review
Supports clinician awareness of serotonin syndrome with serotonergic agents; leaves open precise incidence and risk quantification.
Serotonin syndrome is a potentially fatal condition, associated with drugs that interfere with the serotonergic system. It may occur either from a single agent, or, more commonly, from a combination of serotonergic drugs, or as a result of a drug interaction. The frequency of the syndrome is unknown but probably rising.
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N. Langford (2002) studied this question. Serotonergic drugs and their interactions can cause serotonin syndrome, a potentially fatal condition with an unknown but probably rising frequency.