Studies on the Pathogenesis of Rheumatoid Joint Inflammation

Article1 February 1965Studies on the Pathogenesis of Rheumatoid Joint InflammationIII. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma GlobulinRONALD A. RESTIFO, M.D., ANDRE J. LUSSIER, M.D., ARNOLD J. RAWSON, M.D., JOHN H. ROCKEY, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P.RONALD A. RESTIFO, M.D.Search for more papers by this author, ANDRE J. LUSSIER, M.D.Search for more papers by this author, ARNOLD J. RAWSON, M.D.Search for more papers by this author, JOHN H. ROCKEY, M.D.Search for more papers by this author, JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe finding of leukocytes containing cytoplasmic inclusion granules ("R.A. cells") in the synovial fluids of rheumatoid patients has stimulated an hypothesis for the pathogenesis of the inflammatory changes in this disease (1). This proposes that the inflamed joint results from the phagocytosis of intra-articular complexes of rheumatoid factor and 7S gamma globulin by leukocytes. Supporting such a concept are the release of rheumatoid factor from washed rheumatoid synovial fluid cells fractured by ultrasound (2), the demonstration of intracytoplasmic particulate 7S and 19S gamma globulin in rheumatoid synovial fluid leukocytes (3), and the in vitro phagocytosis of complexes of rheumatoid factor...References1. HOLLANDERRAWSONRESTIFOLUSSIER JLAJRAAJ: Studies on the pathogenesis of rheumatoid joint inflammation (abstract). Arthritis Rheum. 7: 314, 1964. Google Scholar2. HOLLANDERMCCARTYASTORGACASTRO-MURILLO JLDJGC: Studies on the pathogenesis of rheumatoid joint inflammation. I. The "R.A." cell and a working hypothesis. Ann. Intern. Med. 62: 271, 1965. LinkGoogle Scholar3. RAWSONABELSONHOLLANDER AJNMJL: Studies on the pathogenesis of rheumatoid joint inflammation. II. Intracytoplasmic particulate complexes in rheumatoid synovial fluids. Ann. Intern. Med. 62: 281, 1965. LinkGoogle Scholar4. PARKERSCHMID RLFR: Phagocytosis of particulate complexes of gamma globulin and rheumatoid factor. J. Immun. 88: 519, 1962. MedlineGoogle Scholar5. LOWRYBESSEY OHOH: The adaptation of the Beckman spectrophotometer to measurements in minute quantities of biological materials. J. Biol. Chem. 163: 633, 1946. CrossrefMedlineGoogle Scholar6. SCHEIDEGGER JJ: Unc. micro-methode de l' immuno-electrophorese. Int. Arch. Allerg. 7: 103, 1955. CrossrefGoogle Scholar7. CECILNICHOLSSTAINSBY RLEEWJ: The etiology of rheumatoid arthritis. Amer. J. Med. Sci. 181: 12, 1931. CrossrefGoogle Scholar8. WAALER E: On occurrence of factor in human serum activating specific agglutination of sheep blood corpuscles. Acta Path. Microbiol. Scand. 17: 172, 1940. CrossrefGoogle Scholar9. ROSERAGANPEARCELIPMAN HWCEMO: Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis. Proc. Soc. Exp. Biol. Med. 68: 1, 1948. CrossrefMedlineGoogle Scholar10. HARRISVAUGHAN JJH: Transfusion studies in rheumatoid arthritis. Arthritis Rheum. 4: 47, 1961. CrossrefMedlineGoogle Scholar11. Immunological aspects of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 6: Aug. 402, 441, 1963. Google Scholar12. ISHIAZAKAISHIAZAKA IZ: Biologic activities of aggregated gamma globulin. I. Skin reactive and complement fixing properties of heat denatured gamma globulin. Proc. Soc. Exp. Biol. Med. 101: 845, 1959. CrossrefMedlineGoogle Scholar13. CHRISTIAN CL: Properties of aggregated human gamma globulin (abstract). Arthritis Rheum. 3: 268, 1960. Google Scholar14. JAMESHENNEYSTANWORTH KCSDR: Structural changes occurring in 7S gamma globulin. Nature (London) 202: 563, 1964. CrossrefMedlineGoogle Scholar15. OSTERLANDHARBOEKUNKEL CKMHG: Rheumatoid factor (7S and 19S types) reacting with different portions of the gamma globulin molecule. Arthritis Rheum. 5: 312, 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD A. RESTIFO, M.D.; ANDRE J. LUSSIER, M.D.; ARNOLD J. RAWSON, M.D.; JOHN H. ROCKEY, M.D.; JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Arthritis Section, Department of Medicine, and the Department of Surgical Pathology, Hospital of the University of Pennsylvania, and the Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pa.Requests for reprints should be addressed to Joseph Lee Hollander, M.D., Hospital of the University of Pennsylvania, 34th and Spruce Sts., Philadelphia, Pa. 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe subcutaneous air pouch model of synovium and the inflammatory response to heat aggregated gammaglobulinImmunoelectronmicroscopic Characterization of Intracellular Inclusions in Synovial Fluid Cells of Patients with Rheumatoid ArthritisRheumatoid factor: Its nature, specificity, and production in rheumatoid arthritisIdentification of immunoglobulins and complement in rheumatoid articular collagenous tissuesExperimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunityAntigammaglobuline menschlicher HerkunftCellular immunological aspects of rheumatoid arthritisThe Immunopathology of Joint Inflammation in Rheumatoid ArthritisEffect of Gold Salts and Antimalarials on the Rheumatoid Factor in Rheumatoid ArthritisLysozyme in rheumatic diseasesStructure of Synovial Membrane in Rheumatoid ArthritisBeitrag zur Kenntnis der juvenilen monartikul�ren rheumatoiden ArthritisEtiology and Pathogenesis of Rheumatoid ArthritisEXPERIMENTAL ANTI-γG-GLOBULINS IN INFECTIOUS DISEASESAntiglobulins and Human DiseasePresent Status of the Rheumatoid FactorProphylactic AntibioticsCytotoxic Drugs in Rheumatoid ArthritisStudies of isolated synovial lining cells of rheumatoid and nonrheumatoid synovial membranesFurther speculation on the pathogenesis of joint inflammation in rheumatoid arthritisRELATION OF RHEUMATOID FACTOR TO INTRACELLULAR INCLUSIONS*EXPERIMENTAL ARTHRITIS IN MAN AND RABBIT DEPENDENT UPON SERUM ANTI-IMMUNOGLOBULIN FACTORS*The removal of aggregated and nonaggregated autologous gamma globulin from rheumatoid jointsResponse of Sensitized Rabbits to Intra-articular Gamma GlobulinLaboratory Studies in the Diagnosis of Rheumatoid ArthritisIntracytoplasmic inclusions of immunoglobulins in rheumatoid arthritis and other diseasesRelation of intracytoplasmic inclusions in joint fluid leukocytes to anti-γG globulinsThe chronicity of inflammation and its significance in rheumatoid arthritis.Autoimmunity in Rheumatoid ArthritisAutosensitivity DiseasesFurther studies on the pathogenesis of rheumatoid joint inflammationExamination of Synovial Fluid as a Diagnostic Aid in ArthritisEffects of rheumatoid factor on complement levels in vivoAUTOIMMUNITY TO INFLAMMATORY EXUDATESHYPERTENSION AND LIMB LENGTHENINGNonsteroid Antiinflammatory AgentsPolyarthritis psoriaticaStudies on the Pathogenesis of Rheumatoid Joint Inflammation I. The "R.A. Cell" and a Working HypothesisJOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D. 1 February 1965Volume 62, Issue 2Page: 285-291KeywordsArthritisCellsGlobulinsHospital medicineInflammationPathogenesisPhagocytosisSurgical pathologySynovial fluidUltrasound imaging ePublished: 1 December 2008 Issue Published: 1 February 1965 PDF downloadLoading ...