Key result
Pulmonary valve replacement in adults after tetralogy repair was associated with decreased right ventricular size in 81% of patients (P<0.001) and an estimated 50% valve replacement rate at 11 years.
Why the study?
Does pulmonary valve replacement improve outcomes and symptomatology in adults with moderate/severe pulmonary regurgitation after tetralogy repair?
Population
93 adults with moderate/severe pulmonary regurgitation after tetralogy repair, average age 26 years.
Design
Cohort
Follow-up
3 years (range 4 days-28 years)
Authors
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May support PVR for RV size reduction after tetralogy repair; leaves open effects on symptoms and hard outcomes.
Observational (n=93)
Yes
Does pulmonary valve replacement improve outcomes and symptomatology in adults with moderate/severe pulmonary regurgitation after tetralogy repair?
In adults with pulmonary regurgitation after tetralogy repair, pulmonary valve replacement is associated with decreased RV size and improved symptoms, with an average valve durability of approximately 11 years.
Graham et al. (2008) conducted an observational in moderate/severe pulmonary regurgitation after tetralogy repair (n=93). Pulmonary valve replacement was evaluated on Durability of PVR (valve replacement at 11 years). Pulmonary valve replacement in adults after tetralogy repair was associated with decreased right ventricular size in 81% of patients (P<0.001) and an estimated 50% valve replacement rate at 11 years.
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