January 1, 2011Thrombosis and Haemostasis
Venous thromboembolism in patients with symptomatic atherosclerosis
Key result
Patients with venous thromboembolism and symptomatic atherosclerosis had a significantly higher rate of in-hospital major bleeding compared to those without atherosclerosis (7.6% vs. 3.8%, p=0.0008).
Why the study?
Does the presence of symptomatic atherosclerosis increase the risk of adverse outcomes such as major bleeding in patients with venous thromboembolism?
Population
1,818 consecutive patients with validated venous thromboembolism from the population-based Worcester VTE…
Comparison
Presence of symptomatic atherosclerotic… vs Absence of symptomatic atherosclerotic…
Design
Cohort
Follow-up
in-hospital
Authors
Discussion
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Overview
Supports bleeding vigilance in VTE with atherosclerosis; leaves open optimal prophylaxis strategies.
Study Design
Type
Cohort (n=1,822)
Structured PICO
Does the presence of symptomatic atherosclerosis increase the risk of adverse outcomes such as major bleeding in patients with venous thromboembolism?
P
Population
1,822 consecutive patients with validated venous thromboembolism, evaluated to compare outcomes between those with and without symptomatic atherosclerotic cardiovascular disease.
E
Exposure
Presence of symptomatic atherosclerotic cardiovascular disease (history of ischaemic heart disease, positive cardiac catheterisation, percutaneous coronary intervention, coronary artery bypass graft surgery, or peripheral artery disease)
C
Comparator
Absence of symptomatic atherosclerotic cardiovascular disease
O
Outcome
In-hospital major bleedinghard clinical
Main Result
Absolute Event Rate: 7.6% vs 3.8%
p-value: p=0.0008
Patients with VTE and comorbid symptomatic atherosclerosis have a higher risk of in-hospital major bleeding and frequently receive inadequate thromboprophylaxis.
Cite This Study
Goldhaber et al. (2011) conducted a cohort in Venous thromboembolism (n=1,822). Symptomatic atherosclerotic cardiovascular disease vs. No symptomatic atherosclerotic cardiovascular disease was evaluated on In-hospital major bleeding (p=0.0008). Patients with venous thromboembolism and symptomatic atherosclerosis had a significantly higher rate of in-hospital major bleeding compared to those without atherosclerosis (7.6% vs. 3.8%, p=0.0008).