Population
Arterially perfused rat heart under quiescent conditions
Comparison
Increased extracellular potassium concentrations vs Control conditions (6 mM K)
Design
Preclinical
Authors
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May increase resting myocardial energy use in hyperkalemia; hypothesis-generating for Na-K pump energetics in vivo.
Increasing extracellular potassium in resting rat hearts increases energy expenditure, primarily driven by Na-K pump activity and partially by sarcoplasmic reticulum activity.
Ponce‐Hornos et al. (1992) studied this question.
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