Population
Arterially perfused quiescent adult rat hearts
Comparison
Extracellular calcium removal with or without… vs Baseline/normal calcium conditions
Design
Preclinical
Authors
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May model mitochondrial calcium cycling in heart failure energetics; hypothesis-generating and should not yet change practice.
Energy expenditure for resting state maintenance upon calcium withdrawal depends on intracellular rises in sodium and calcium, suggesting mitochondrial calcium cycling that may simulate pathological conditions like heart failure.
Bonazzola et al. (2010) studied this question.
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