Key result
Autoantibodies against alanyl-tRNA synthetase were detected in 50% of patients with idiopathic pulmonary fibrosis compared to 0% of healthy controls.
Why the study?
Do patients with idiopathic pulmonary fibrosis possess circulating autoantibodies against alanyl-tRNA synthetase?
Population
22 patients with idiopathic pulmonary fibrosis who had no clinical symptoms of collagen vascular disease, 37…
Design
Case-control
Authors
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May suggest autoimmune involvement in IPF; hypothesis-generating and should not yet change practice.
Case-Control (n=100)
Do patients with idiopathic pulmonary fibrosis possess circulating autoantibodies against alanyl-tRNA synthetase?
Absolute Event Rate: 50% vs 0%
A significant proportion of patients with idiopathic pulmonary fibrosis possess circulating autoantibodies against alanyl-tRNA synthetase, suggesting an autoimmune component in its pathogenesis.
Takahashi et al. (2007) conducted a case-control in Idiopathic pulmonary fibrosis (n=100). Autoantibodies to alanyl-tRNA synthetase vs. Healthy subjects and patients with collagen vascular disease was evaluated on Positive immunostaining for autoantibodies. Autoantibodies against alanyl-tRNA synthetase were detected in 50% of patients with idiopathic pulmonary fibrosis compared to 0% of healthy controls.
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