Key result
Antiarrhythmic drugs markedly depressed conduction and excitability in ischemic rabbit heart tissue while having minimal effects on normal perfused tissue.
Why the study?
Do antiarrhythmic drugs selectively depress conduction and excitability in ischemic tissue compared to normal tissue in Langendorff-perfused rabbit hearts?
Population
Langendorff-perfused rabbit hearts
Comparison
Antiarrhythmic drugs at therapeutic concentrations vs Normal perfused tissue
Design
Preclinical
Authors
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Warrants caution against clinical extrapolation; leaves open ischemia-selective antiarrhythmic targeting for future translational studies.
Do antiarrhythmic drugs selectively depress conduction and excitability in ischemic tissue compared to normal tissue in Langendorff-perfused rabbit hearts?
Antiarrhythmic drugs selectively depress abnormal electrical activity in ischemic cardiac tissue while sparing normal tissue in a rabbit heart model.
Hondeghem et al. (1978) studied Cardiac ischemia. Antiarrhythmic drugs vs. Normal (perfused) tissue was evaluated on Conduction and excitability. Antiarrhythmic drugs markedly depressed conduction and excitability in ischemic rabbit heart tissue while having minimal effects on normal perfused tissue.
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