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In a 51Cr‐release assay system it is found that serum from normal women with pregnancy‐induced lymphocyte allo‐antibody can cooperate with normal non‐sensitized peripheral human leucocytic cells in producing cytotoxic activity against target cells from the husband. Conventional complement activation is not involved. The cooperating serum factor is found to be antibody and is located in the IgG fraction. The effector cells are lymphocytes and the activity is blocked by cytochalasin B.
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Ebbe Dickmeiss (1973) studied this question.
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