Key result
Enteric viruses were isolated in 14.4% of sudden infant death cases compared to 3.0% of controls, but the frequency was too low to be significant in this sample size.
Why the study?
Is viral infection associated with sudden unexpected death in infancy?
Population
130 infants, comprising 97 cases of sudden unexpected death and 33 comparable control cases.
Comparison
Presence of enteric viruses (viral infection) vs Control cases (infants without sudden death)
Design
Case-control
Authors
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No change to SUDI evaluation; leaves open possible enteric virus role but requires larger studies before any inference.
Case-Control (n=130)
Is viral infection associated with sudden unexpected death in infancy?
Absolute Event Rate: 14.4% vs 3%
While Coxsackie B viruses were isolated from necropsy tissues in some sudden infant death cases, the overall frequency of viral isolation was too low to establish a definitive causal link in this sample.
Balduzzi et al. (1966) conducted a case-control in Sudden unexpected death in infancy (n=130). Enteric viruses vs. Control cases was evaluated on Isolation of viral strains. Enteric viruses were isolated in 14.4% of sudden infant death cases compared to 3.0% of controls, but the frequency was too low to be significant in this sample size.
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