Key result
Endurance and HIIT decreased low-molecular weight adiponectin and increased GLUT4 levels (p<0.05), while endurance training reversed HFD-induced decreases in high-molecular weight adiponectin.
Why the study?
Adiponectin plays a key role in cardiomyocyte metabolism, but the effects of exercise during obesity on cardiac adiponectin levels remain unclear.
Does constant-moderate endurance or high-intensity interval training alter heart adiponectin levels in high-fat fed mice?
Does constant-moderate endurance or high-intensity interval training alter heart adiponectin levels in high-fat fed mice?
p-value: p=< 0.05
Exercise training, particularly constant-moderate endurance, modulates heart adiponectin isoforms and GLUT4 levels in mice on a high-fat diet, suggesting a role in regulating cardiomyocyte metabolism.
Hypothesis-generating for exercise effects on cardiac adiponectin in obesity; clinical trials needed before human translation.
Context Research has described that adiponectin plays a key role in cardiomyocytes metabolism, however, the effects of exercise during obesity on cardiac adiponectin levels is unclear.Objective To investigate the effects of constant-moderate endurance (END) and high-intensity interval training (HIIT), on heart adiponectin levels in mice.Material and methods Two experiments were conducted: (1) preventive (EX1): 10 week-old male mice were fed standard (CHOW) or high-fat diet (HFD;45% fat) and simultaneously trained with END and HIIT for 10 weeks; (2) Treatment (EX2): after 10 weeks of dietary intervention, another cohort of 10 week-old mice were trained by both programmes for 10 weeks.Results In EX1, END and HIIT decreased low-molecular weight adiponectin (∼0.5-fold; p < 0.05) and increased GLUT4 levels (∼2-fold; p < .05). In EX2, HFD significantly decreased high-molecular weight adiponectin (∼0.7-fold; p < .05), and END reversed this change.Discussion and conclusion: HFD and exercise influence heart adiponectin isoforms and therefore might impact cardiomyocyte metabolism.
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Martínez-Huenchullán et al. (2020) studied Obesity. Constant-moderate endurance (END) and high-intensity interval training (HIIT) vs. Standard diet (CHOW) or untrained high-fat diet (HFD) was evaluated on Heart adiponectin and GLUT4 levels (p=< 0.05). Endurance and HIIT decreased low-molecular weight adiponectin and increased GLUT4 levels (p<0.05), while endurance training reversed HFD-induced decreases in high-molecular weight adiponectin.
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