Why the study?
Does lower body negative pressure (cardiopulmonary baroreceptor deactivation) alter renal hemodynamics and neurohumoral factors in normal males?
Does lower body negative pressure (cardiopulmonary baroreceptor deactivation) alter renal hemodynamics and neurohumoral factors in normal males?
Cardiopulmonary baroreflex deactivation by lower body negative pressure reduces glomerular filtration rate and filtration fraction, likely mediated by a decrease in atrial natriuretic factor rather than vasoconstrictor activation.
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May link baroreceptor unloading to reduced GFR via ANF in normals; hypothesis-generating for cardiorenal mechanisms in HF.
Miller et al. (1991) studied this question.
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