What question did this study set out to answer?

This research aims to understand how cardiopulmonary receptors influence plasma renin activity in both normotensive and hypertensive humans.

January 1, 1988HypertensionOpen Access

Cardiopulmonary receptor modulation of plasma renin activity in normotensive and hypertensive subjects.

View Full Paper

Ask AI

Bookmark

Why the study?

Does cardiopulmonary receptor modulation alter plasma renin activity in normotensive and hypertensive subjects?

Population

24 subjects (12 normotensive and 12 age-matched subjects with untreated mild or moderate hypertension)

Comparison

Cardiopulmonary receptor stimulation and… vs Baseline values and comparison between…

Design

Other

Follow-up

20 to 30 minutes

Authors

GGGuıdo GrassıGeneral / Preventive / Lipids CGCristina GiannattasioGeneral Cardiology ASAntonio SainoAzienda Ospedaliera Bolognini Seriate

Discussion

Member takes

Implication

Blunted cardiopulmonary renin reflex in hypertension should not yet change practice; leaves open its mechanistic role and therapeutic relevance.

Key Points

This research aims to understand how cardiopulmonary receptors influence plasma renin activity in both normotensive and hypertensive humans.
Studied 12 normotensive and 12 hypertensive subjects.
Stimulated and deactivated cardiopulmonary receptors using central venous pressure and cardiac volume changes.
Measured plasma renin activity through radioimmunoassay.
In normotensive subjects, deactivation of cardiopulmonary receptors caused a significant rise in plasma renin activity.
In hypertensive subjects, changes in plasma renin activity were observed but were less pronounced than in normotensive subjects.
The reflex gain ratio was similar during both stimulation and deactivation of cardiopulmonary receptors.

Structured PICO

Does cardiopulmonary receptor modulation alter plasma renin activity in normotensive and hypertensive subjects?

Population

24 subjects (12 normotensive and 12 age-matched subjects with untreated mild or moderate hypertension)

Intervention

Cardiopulmonary receptor stimulation (via passive leg raising) and deactivation (via lower body negative pressure) maintained for 20 to 30 minutes

Comparator

Baseline values and comparison between normotensive and hypertensive groups

Outcome

Plasma renin activitysurrogate

Cardiopulmonary receptors modulate plasma renin activity in humans, but this reflex control is blunted in patients with mild to moderate hypertension.

Cite This Study

Grassı et al. (1988) studied this question.

synapsesocial.com/papers/6a71f4f2ac440176ef2a70bb https://doi.org/10.1161/01.hyp.11.1.92

View Full Paper

Ask AI

Bookmark

Implication

Blunted cardiopulmonary renin reflex in hypertension should not yet change practice; leaves open its mechanistic role and therapeutic relevance.

Cardiopulmonary receptor modulation of plasma renin activity in normotensive and hypertensive subjects.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiopulmonary receptor modulation of plasma renin activity in normotensive and hypertensive subjects.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider