Key result
Acute changes in cardiopulmonary blood volume showed that sensitivity of neural control of renin release was not statistically different between normal and hypertensive subjects, but decreased with age.
Why the study?
Do acute changes in cardiopulmonary blood volume affect plasma renin activity differently in normal versus hypertensive humans?
Population
20 subjects, including 9 normotensive controls and 11 essential hypertensive patients of the same age
Comparison
Acute changes in cardiopulmonary blood volume… vs Normotensive controls compared to essential…
Design
Other
Authors
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Age-related decline in cardiopulmonary reflex sensitivity for renin release, independent of hypertension status; hypothesis-generating and should not yet change practice.
Observational (n=20)
Do acute changes in cardiopulmonary blood volume affect plasma renin activity differently in normal versus hypertensive humans?
Aging, rather than hypertension status, appears to be the primary factor influencing the sensitivity of neural control of renin release in response to cardiopulmonary blood volume changes.
London et al. (1985) conducted an observational in Essential hypertension (n=20). Acute changes in cardiopulmonary blood volume (head-down tilt and thigh-cuff inflation) vs. Normotensive controls was evaluated on Sensitivity of neural control of renin release (delta PRA/delta CPBV). Acute changes in cardiopulmonary blood volume showed that sensitivity of neural control of renin release was not statistically different between normal and hypertensive subjects, but decreased with age.
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